Obesity and the Microvasculature: A Systematic Review and Meta-Analysis
Identifieur interne : 004571 ( Main/Exploration ); précédent : 004570; suivant : 004572Obesity and the Microvasculature: A Systematic Review and Meta-Analysis
Auteurs : Adrien Boillot [France] ; Sophia Zoungas [Australie] ; Paul Mitchell [Australie] ; Ronald Klein [États-Unis] ; Barbara Klein [États-Unis] ; Mohammad Kamran Ikram [Singapour, Pays-Bas] ; Caroline Klaver [Pays-Bas] ; Jie Jin Wang [Australie] ; Bamini Gopinath [Australie] ; E. Shyong Tai [Singapour] ; Aljoscha Steffen Neubauer [Allemagne] ; Serge Hercberg [France] ; Laima Brazionis [Australie] ; Seang-Mei Saw [Singapour] ; Tien-Yin Wong [Singapour] ; Sébastien Czernichow [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.
Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m2 increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.
Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.
Url:
DOI: 10.1371/journal.pone.0052708
PubMed: 23405065
PubMed Central: 3566162
Affiliations:
- Allemagne, Australie, France, Pays-Bas, Singapour, États-Unis
- Bavière, District de Haute-Bavière, Hollande-Méridionale, Nouvelle-Galles du Sud, Victoria (État), Wisconsin, Île-de-France
- Bobigny, Boulogne-Billancourt, Melbourne, Munich, Paris, Rotterdam, Sydney, Versailles
- Université Louis-et-Maximilien de Munich, Université de Melbourne, Université nationale de Singapour
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Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Boulogne-Billancourt</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff12"><addr-line>Department of 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id="aff2"><addr-line>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Boulogne-Billancourt</settlement></placeName></affiliation></author><author><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Klein, Barbara" sort="Klein, Barbara" uniqKey="Klein B" first="Barbara" last="Klein">Barbara Klein</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Ikram, Mohammad Kamran" sort="Ikram, Mohammad Kamran" uniqKey="Ikram M" first="Mohammad Kamran" last="Ikram">Mohammad Kamran Ikram</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Klaver, Caroline" sort="Klaver, Caroline" uniqKey="Klaver C" first="Caroline" last="Klaver">Caroline Klaver</name><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Westmead Millennium Institute (Centre for Vision Research), Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Gopinath, Bamini" sort="Gopinath, Bamini" uniqKey="Gopinath B" first="Bamini" last="Gopinath">Bamini Gopinath</name><affiliation wicri:level="4"><nlm:aff id="aff9"><addr-line>Department of Medicine, University of Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, University of Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E. Shyong" last="Tai">E. Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Neubauer, Aljoscha Steffen" sort="Neubauer, Aljoscha Steffen" uniqKey="Neubauer A" first="Aljoscha Steffen" last="Neubauer">Aljoscha Steffen Neubauer</name><affiliation wicri:level="4"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Ludwig-Maximilians University, Muenchen, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, Ludwig-Maximilians University, Muenchen</wicri:regionArea><wicri:noRegion>Muenchen</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation wicri:level="3"><nlm:aff id="aff11"><addr-line>Unité de Recherche en Épidémiologie Nutritionnelle, Institut National de la Recherche Agronomique/Institut National de la Recherche et de la Santé Médicale, Unité U557/Avicenne Hospital/Conservatoire des Arts et Métiers/Université Paris 13/Université Sorbone Paris Cité, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche en Épidémiologie Nutritionnelle, Institut National de la Recherche Agronomique/Institut National de la Recherche et de la Santé Médicale, Unité U557/Avicenne Hospital/Conservatoire des Arts et Métiers/Université Paris 13/Université Sorbone Paris Cité, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Brazionis, Laima" sort="Brazionis, Laima" uniqKey="Brazionis L" first="Laima" last="Brazionis">Laima Brazionis</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Vascular Sciences and Medicine, The George Institute for Global Health, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Department of Ophthalmology, Singapore Eye Research Institute, Singapore, Singapore</addr-line></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Ophthalmology, Singapore Eye Research Institute, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Ambroise Paré Hospital, Boulogne-Billancourt</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Boulogne-Billancourt</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff12"><addr-line>Department of Nutrition, Université Versailles St-Quentin, Versailles, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Nutrition, Université Versailles St-Quentin, Versailles</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Versailles</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13"><addr-line>Institut National de la Recherche et de la Santé Médicale, Unité 1018, Centre for Research in Epidemiology and Population Health, Population-based Cohorts Research Platform, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Recherche et de la Santé Médicale, Unité 1018, Centre for Research in Epidemiology and Population Health, Population-based Cohorts Research Platform, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber.</p></sec><sec><title>Methods and Findings</title><p>Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m<sup>2</sup> increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children.</p></sec><sec><title>Conclusions</title><p>Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. 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Cairella</name></author><author><name sortKey="Garbagnati, F" uniqKey="Garbagnati F">F Garbagnati</name></author><author><name sortKey="Cappuccio, Fp" uniqKey="Cappuccio F">FP Cappuccio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ageno, W" uniqKey="Ageno W">W Ageno</name></author><author><name sortKey="Becattini, C" uniqKey="Becattini C">C Becattini</name></author><author><name sortKey="Brighton, T" uniqKey="Brighton T">T Brighton</name></author><author><name sortKey="Selby, R" uniqKey="Selby R">R Selby</name></author><author><name sortKey="Kamphuisen, Pw" uniqKey="Kamphuisen P">PW Kamphuisen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Czernichow, S" uniqKey="Czernichow S">S Czernichow</name></author><author><name sortKey="Kengne, Ap" uniqKey="Kengne A">AP Kengne</name></author><author><name sortKey="Stamatakis, E" uniqKey="Stamatakis E">E Stamatakis</name></author><author><name sortKey="Hamer, M" uniqKey="Hamer M">M Hamer</name></author><author><name sortKey="Batty, Gd" uniqKey="Batty G">GD Batty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgeechan, K" uniqKey="Mcgeechan K">K McGeechan</name></author><author><name sortKey="Liew, G" uniqKey="Liew G">G Liew</name></author><author><name sortKey="Macaskill, P" uniqKey="Macaskill P">P Macaskill</name></author><author><name sortKey="Irwig, L" uniqKey="Irwig L">L Irwig</name></author><author><name sortKey="Klein, R" uniqKey="Klein R">R Klein</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Pays-Bas</li><li>Singapour</li><li>États-Unis</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Hollande-Méridionale</li><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li><li>Wisconsin</li><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>Boulogne-Billancourt</li><li>Melbourne</li><li>Munich</li><li>Paris</li><li>Rotterdam</li><li>Sydney</li><li>Versailles</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université de Melbourne</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Boillot, Adrien" sort="Boillot, Adrien" uniqKey="Boillot A" first="Adrien" last="Boillot">Adrien Boillot</name></region><name sortKey="Boillot, Adrien" sort="Boillot, Adrien" uniqKey="Boillot A" first="Adrien" last="Boillot">Adrien Boillot</name><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sébastien" last="Czernichow">Sébastien Czernichow</name><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name></country><country name="Australie"><noRegion><name sortKey="Zoungas, Sophia" sort="Zoungas, Sophia" uniqKey="Zoungas S" first="Sophia" last="Zoungas">Sophia Zoungas</name></noRegion><name sortKey="Brazionis, Laima" sort="Brazionis, Laima" uniqKey="Brazionis L" first="Laima" last="Brazionis">Laima Brazionis</name><name sortKey="Gopinath, Bamini" sort="Gopinath, Bamini" uniqKey="Gopinath B" first="Bamini" last="Gopinath">Bamini Gopinath</name><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name></country><country name="États-Unis"><region name="Wisconsin"><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name></region><name sortKey="Klein, Barbara" sort="Klein, Barbara" uniqKey="Klein B" first="Barbara" last="Klein">Barbara Klein</name></country><country name="Singapour"><noRegion><name sortKey="Ikram, Mohammad Kamran" sort="Ikram, Mohammad Kamran" uniqKey="Ikram M" first="Mohammad Kamran" last="Ikram">Mohammad Kamran Ikram</name></noRegion><name sortKey="Ikram, Mohammad Kamran" sort="Ikram, Mohammad Kamran" uniqKey="Ikram M" first="Mohammad Kamran" last="Ikram">Mohammad Kamran Ikram</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E. Shyong" last="Tai">E. Shyong Tai</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien-Yin" last="Wong">Tien-Yin Wong</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Ikram, Mohammad Kamran" sort="Ikram, Mohammad Kamran" uniqKey="Ikram M" first="Mohammad Kamran" last="Ikram">Mohammad Kamran Ikram</name></region><name sortKey="Klaver, Caroline" sort="Klaver, Caroline" uniqKey="Klaver C" first="Caroline" last="Klaver">Caroline Klaver</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Neubauer, Aljoscha Steffen" sort="Neubauer, Aljoscha Steffen" uniqKey="Neubauer A" first="Aljoscha Steffen" last="Neubauer">Aljoscha Steffen Neubauer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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